Author

Lindsay E. Lathrop

University of California, Los AngelesORCID 0009-0005-1154-9116Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:CRISPR screen· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Donald B. KohniD· 3 shared Beate IllekiD· 2 shared Brigitte N. GompertsiD· 2 shared Colin J. JuettiD· 2 shared Emily C. DugganiD· 2 shared Paul George AyoubiD· 2 shared Ruth A. FoleyiD· 2 shared Steven John JonasiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBioengineering

Donald B. KohnORCID

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3 papers

Recent·Most cited

BioengineeringAdvanced Functional MaterialsPeer-reviewedJan 4, 2026

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site-Specific Integration of CFTR and Mutation-Agnostic Disease Rescue

Ruth A. Foley, Paul George Ayoub, Vrishti Sinha…·Steven John Jonas

This paper develops lipid nanoparticles to deliver CRISPR/Cas9 for site-specific CFTR gene integration in CF airway cells, achieving 3-3.5% gene editing and 80% Cl- current restoration.

8 citationstop 3%

humanCRISPR screen

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GeneticsbioRxivPreprintSep 21, 2025

Investigation of Double-Stranded DNA Donors and CRISPR-Cas9 RNP for Universal Correction of Mutations Causing Cystic Fibrosis in Human Airway Cells

Vrishti Sinha, Paul George Ayoub, Colin J. Juett…·Donald B. Kohn

This study demonstrates that low levels of CFTR integration can restore chloride ion currents in human airway cells using optimized nonviral CRISPR-Cas9 RNP and double-stranded DNA donors.

DOI 10.1101/2025.09.21.677613

humanCRISPR screen

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BioengineeringbioRxivPreprintNov 25, 2024

Stage-specific CAR-mediated signaling generates naive-like, TCR-null CAR T cells from induced pluripotent stem cells

Sang Pil Yoo, Xuegang Yuan, Claire Engstrom…·Gay M. Crooks

This study generates TCR-null CAR T cells from iPSCs by controlling CAR signaling stages, resulting in naive-like cells with enhanced cytotoxicity.

2 citations

humanbulk RNA-seq

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