SELECTIVE ACTIVATION OF GIRK POTASSIUM CHANNELS REDUCES BEHAVIORAL AND BRAIN RESPONSES TO ETHANOL IN MICE
Jaume J. Taura, Arianna Marrazzo, Se In Son, Ganesha Rai, Max Kreifeldt, Candice Contet, Paul A. Slesinger
This study shows that activating GIRK channels with GiGA1 reduces ethanol reward and intake in mice, suggesting it as a potential treatment for AUD.
bioRxiv · Feb 2, 2026 · PreprintNeuroscience