Ganesha Rai

Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR

The paper introduces a method to infer isoform-level kinetics of nonsense-mediated mRNA decay using short-read NR-seq data, revealing variability in NMD efficiency and decay rates of transcripts with and without PTCs.

SELECTIVE ACTIVATION OF GIRK POTASSIUM CHANNELS REDUCES BEHAVIORAL AND BRAIN RESPONSES TO ETHANOL IN MICE

This study shows that activating GIRK channels with GiGA1 reduces ethanol reward and intake in mice, suggesting it as a potential treatment for AUD.

Small Molecule Antiviral Compound Collection (SMACC): a database to support the discovery of broad-spectrum antiviral drug molecules.

The paper curates a database of antiviral compounds tested against 13 emerging viruses, identifies potential broad-spectrum antivirals, and highlights the need for coordinated research efforts.

Allosteric binders of ACE2 are promising anti-SARS-CoV-2 agents

The paper identifies five compounds that inhibit SARS-CoV-2 replication by binding to ACE2 without disrupting its enzymatic function, serving as potential acute treatments for COVID-19.