Candice Contet

Functional remodeling of the parasubthalamic nucleus drives alcohol drinking escalation in dependence

This study identifies PSTN Crh neurons as a key driver of alcohol drinking escalation in dependence, showing their role shifts from inhibitory to stimulatory with dependence.

SELECTIVE ACTIVATION OF GIRK POTASSIUM CHANNELS REDUCES BEHAVIORAL AND BRAIN RESPONSES TO ETHANOL IN MICE

This study shows that activating GIRK channels with GiGA1 reduces ethanol reward and intake in mice, suggesting it as a potential treatment for AUD.

Mouse parasubthalamic Crh neurons drive alcohol drinking escalation and behavioral disinhibition

This study identifies PSTN Crh neurons as drivers of alcohol drinking escalation and behavioral disinhibition in mice, independent of CRF1 signaling.

Ethanol's interaction with BK channel α subunit residue K361 does not mediate behavioral responses to alcohol in mice

This study investigates whether ethanol's interaction with BK channel α subunit residue K361 mediates behavioral responses to alcohol in mice, finding no significant effects on ethanol-related behaviors or consumption.

The parasubthalamic nucleus refeeding ensemble delays feeding initiation

This study identifies PSTN neuron subpopulations that regulate feeding initiation and consumption behaviors in mice during refeeding.

Chemogenetic stimulation of mouse central amygdala corticotropin-releasing factor neurons: Effects on cellular and behavioral correlates of alcoholdependence

This study investigates the role of CeA CRF neurons in alcohol dependence by using chemogenetics to assess their impact on behavior and neurotransmission during withdrawal.

Single-cell whole-brain imaging and network analysis provide evidence of the three-stage hypothesis of addiction

The paper validates the three-stage theory of addiction using single-cell whole-brain imaging in a mouse model, showing abstinence reduces brain modularity and clusters regions corresponding to each stage.

Knockdown of Hypocretin/Orexin Attenuates Extended-Access Cocaine Self-Administration in Rats

This study shows that knocking down hypocretin/orexin in rats reduces cocaine self-administration during extended access, suggesting a role in compulsive drug-taking behavior.