Author

Sean C. Shadle

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Bradley Robert CairnsiD· 2 shared Edward J. GrowiD· 2 shared Amy E. CampbelliD· 1 shared Brenda BassiD· 1 shared Chao-Jen Wong· 1 shared Christina M. SmithiD· 1 shared Irina A. PolejaevaiD· 1 shared Iuri Viótti PérisséiD· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersDevelopmental Biology

Bradley Robert CairnsORCID

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3 papers

Recent·Most cited

Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation

Edward J. Grow, Ying Liu, Zhiqiang Fan, Iuri Viótti Périssé, Tayler Patrick, Misha Regouski, Sean C. Shadle, Irina A. Polejaeva, Kenneth L. White, Bradley Robert Cairns

The paper investigates chromatin reprogramming during embryonic genome activation in bovine embryos, finding that SCNT embryos fail to reprogram certain EGA gene targets and that DUXC over-expression can rescue this defect.

bioRxiv · Apr 10, 2023 · PreprintDevelopmental Biology

Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program

Christina M. Smith, Edward J. Grow, Sean C. Shadle, Bradley Robert Cairns

The paper identifies active and inactive regions within mouse DUX that recruit chromatin regulators to enhance the embryonic gene expression program.

bioRxiv · Mar 29, 2023 · PreprintDevelopmental Biology

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD

Sean C. Shadle, Sean R. Bennett, Chao-Jen Wong, Nancy Karreman, Amy E. Campbell, Silvère M. van der Maarel, Brenda Bass, Stephen J. Tapscott

This study identifies DUX4-induced bidirectional HSATII satellite repeat transcripts that form intranuclear dsRNA foci contributing to FSHD toxicity.

Human Molecular Genetics · Oct 4, 2019Peer-reviewedMolecular Biology