Brenda Bass

The paper reports cryo-EM structures of the C. elegans antiviral complex DCR-1·DRH-1·RDE-4, showing how these proteins stack and interact to cleave dsRNA.

This study reconstitutes the antiviral Dicer complex in vitro to show RDE-4 stabilizes and activates it, with distinct roles for dsRBM2 and dsRBM3 in ATP hydrolysis and dsRNA cleavage.

This study characterizes Orsay virus replication intermediates in C. elegans, revealing their connection to antiviral RNA interference pathways.

This study reconstructs ancient Dicer helicases to uncover how ATP hydrolysis drives dsRNA translocation and cleavage, revealing evolutionary changes in helicase function across species.

The paper develops dsRNAscan to predict dsRNAs in the human genome, identifies neuronal enrichment and intermolecular interactions, and provides a resource for dsRNA annotations.

This study shows that an shRNA targeting DDX54 can activate PKR through a dsRNA-mediated mechanism, highlighting the need for careful validation of gene function.

This study identifies DUX4-induced bidirectional HSATII satellite repeat transcripts that form intranuclear dsRNA foci contributing to FSHD toxicity.