Edward J. Grow

ECHOS enables spatial epigenome profiling at subcellular resolution by combining high-resolution imaging and high-throughput sequencing, revealing distinct gene regulatory logics and epigenetic changes in human tissues.

The paper identifies ZYG-9/ch-TOG as a spindle pole protein that binds DNA and packages meiotic chromosomes into polar bodies, ensuring proper genome copy number in oocytes.

The paper maps Z-DNA using ChIP-Seq with two Z-DNA biosensors, finding similar binding profiles but distinct gene associations.

The paper investigates chromatin reprogramming during embryonic genome activation in bovine embryos, finding that SCNT embryos fail to reprogram certain EGA gene targets and that DUXC over-expression can rescue this defect.

The paper identifies active and inactive regions within mouse DUX that recruit chromatin regulators to enhance the embryonic gene expression program.

The paper identifies maternally-deposited antisense piRNAs that silence transposons in zebrafish embryos by targeting young LTR retrotransposons and promoting H3K9me2/3 modification.