Sean R. Bennett

DUX4-induced HSATII RNA accumulation drives protein aggregation impacting RNA processing pathways.

The paper shows DUX4 induces HSATII RNA accumulation, leading to protein aggregation and disruption of RNA processing pathways in muscle cells.

A discrete region of the D4Z4 is sufficient to initiate epigenetic silencing

The paper identifies a specific D4Z4 sequence that can epigenetically silence a reporter gene, revealing key regulators and mechanisms of DUX4 repression in skeletal muscle.

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

This study shows DUX4 and mouse Dux interact with STAT1 and inhibit IFN-gamma-induced ISG expression by reducing STAT1 and Pol-II recruitment.

Validation of the association between MRI and gene signatures in facioscapulohumeral dystrophy muscle: implications for clinical trial design

The paper validates the association between MRI characteristics and gene signatures in FSHD muscle, supporting their use as biomarkers for clinical trial design.

DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double stranded RNA foci in human cell models of FSHD

This study identifies DUX4-induced bidirectional HSATII satellite repeat transcripts that form intranuclear dsRNA foci contributing to FSHD toxicity.