Multiple redundant mechanisms account for the majority of gene silencing downstream of DNA methylation
Shuya Wang, Zhongshou Wu, Zheng Li, Andrea Movilli, Li He, Yuxing Zhou, Evan K. Lin, Russell Chuang, Wai Wai Thiri, Sean Convery, Suhua Feng, Detlef Weigel, Steven E. Jacobsen
The paper shows that multiple redundant mechanisms account for most gene silencing downstream of DNA methylation, with loss of these pathways causing widespread derepression and genomic changes.
bioRxiv · Feb 10, 2026 · PreprintMolecular Biology