Zhongshou Wu

This study identifies RRsS1 as a dual-binding scaffold that stabilizes Pol IV transcription complexes to enhance siRNA biogenesis in plant reproduction.

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

This paper identifies a fungal natural product, MDD, as a novel cellulose biosynthesis inhibitor that targets CESA1 and disrupts cellulose synthase complexes, enabling the development of multi-drug resistant crop varieties.

The paper shows that multiple redundant mechanisms account for most gene silencing downstream of DNA methylation, with loss of these pathways causing widespread derepression and genomic changes.

The paper identifies Arabidopsis REM transcription factors and GDE1 as key regulators of DNA methylation by recruiting RNA Polymerase IV to generate 24nt-siRNAs that direct methylation to specific genomic loci.

This study shows that loss of H3.1K27me1 in Arabidopsis leads to resistance against Geminivirus by sequestering DNA repair proteins to defense genes and rDNA, reducing viral replication.