Author

Li He

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Andrea MovilliiD· 1 shared Benjamin M. AlbaiD· 1 shared Detlef WeigeliD· 1 shared Evan K. LiniD· 1 shared Hong Sun· 1 shared Mehma Kaur· 1 shared Peng LiiD· 1 shared Russell Chuang· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Andrea MovilliORCID

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2 papers

Recent·Most cited

Fine-tuning STEAP1 protein expression and purification to preserve its conformation and function

Li He, Sungsoo Yoo, Hong Sun, Vasudha Pathakota, Mehma Kaur, Peng Li, Benjamin M. Alba, Xiao-Jie Yao

This study optimizes STEAP1 expression and purification to preserve its conformation and function, showing improved heme incorporation and protein quality in stable expression systems.

bioRxiv · Feb 19, 2026 · PreprintBiochemistry

Multiple redundant mechanisms account for the majority of gene silencing downstream of DNA methylation

Shuya Wang, Zhongshou Wu, Zheng Li, Andrea Movilli, Li He, Yuxing Zhou, Evan K. Lin, Russell Chuang, Wai Wai Thiri, Sean Convery, Suhua Feng, Detlef Weigel, Steven E. Jacobsen

The paper shows that multiple redundant mechanisms account for most gene silencing downstream of DNA methylation, with loss of these pathways causing widespread derepression and genomic changes.

bioRxiv · Feb 10, 2026 · PreprintMolecular Biology