A single transcriptional regulator is crucial for the adaptation of Staphylococcus aureus to diverse niches
Claus Vogl, Lynette Caitlin Mikula, Helene Marbach, Katharina Mayer-Weihrauch, Sebastian Herndler, Leonie Breitschopf, Amy C. Pickering, Mary-Elizabeth Jobson, Adriana Cabal Rosel, Nora Dinhopl, Igor Loncaric, Werner Ruppitsch, Lindsey Neil Shaw, Orla M. Keane, J. Ross Fitzgerald, , Tom Grunert
This study shows that the transcriptional regulator SigB is crucial for Staphylococcus aureus adaptation to different niches, with SigB-deficient strains evolving in persistent mastitis due to the cost of phenotypic plasticity.
bioRxiv · Aug 1, 2025 · PreprintMicrobiology