An ancestral transmembrane transcription factor couples cell envelope regulation and the SOS response in Caulobacter crescentus
Kamilla Ankær Brejndal, Nikolaj Vestergaard Hansen, Koyel Ghosh, Sebastian Nielsen, Isabella Thorud, Lykke Haastrup Hansen, Lene Andrup Jakobsen, Martin Røssel Larsen, Clare Louise Kirkpatrick
This paper identifies HigX as a membrane-associated transcription factor in Caulobacter crescentus that is induced by the SOS response but negatively affects cell viability, revealing its role in cell envelope regulation and the trade-off between DNA repair and cell envelope stability.
PLoS Genetics · Jul 15, 2026Peer-reviewedMicrobiology