Author

Lene Andrup Jakobsen

University of Southern Denmark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 5 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 6 Organism:human· 5 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:metabolomics· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Martin Røssel LarseniD· 7 shared Helle BogetofteiD· 6 shared Pia JenseniD· 6 shared Jonathan Richard BreweriD· 5 shared Lucrezia CriscuoloiD· 5 shared Jesper Foged HavelundiD· 4 shared Kristine FreudeiD· 4 shared Madeline A. LancasteriD· 4 shared

Activity by Year

2024-2026 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersNeuroscience

Martin Røssel LarsenORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

STEP-PTMs: Sequential TMT-based Enrichment and Profiling of Post-Translational Modifications

Lucrezia Criscuolo, Sofie Blomberg Elmkvist, Arkadiusz Nawrocki, Lene Andrup Jakobsen, Pia Jensen, Peter Toft Jensen, Honggang Huang, Jesper Foged Havelund, Nils Joakim Færgeman, Giuseppe Palmisano, Helle Bogetofte, Martin R. Larsen

STEP-PTM enables integrated quantitative analysis of proteome, metabolome, and multiple PTM classes from single biological samples using a modular TMT-multiplexed workflow.

bioRxiv · Aug 20, 2026 · PreprintBiochemistry

An ancestral transmembrane transcription factor couples cell envelope regulation and the SOS response in Caulobacter crescentus

Kamilla Ankær Brejndal, Nikolaj Vestergaard Hansen, Koyel Ghosh, Sebastian Nielsen, Isabella Thorud, Lykke Haastrup Hansen, Lene Andrup Jakobsen, Martin Røssel Larsen, Clare Louise Kirkpatrick

This paper identifies HigX as a membrane-associated transcription factor in Caulobacter crescentus that is induced by the SOS response but negatively affects cell viability, revealing its role in cell envelope regulation and the trade-off between DNA repair and cell envelope stability.

PLoS Genetics · Jul 15, 2026Peer-reviewedMicrobiology

Protein-state dysregulation and sex-specific neurodevelopmental signatures in schizophrenia forebrain organoids

Helle Bogetofte, Sissel Ida Schmidt, Marie Sejberg Øhlenschlæger, Sofie Blomberg Elmkvist, Pia Jensen, Fadumo Abdullahi Mohamed, Anne With Mikkelsen, Elif Bayram Orbe, Jesper Foged Havelund, Matias Ryding, Lucrezia Criscuolo, Lene Andrup Jakobsen, Arkadiusz Nawrocki, Phillip James Robinson, Madeline A. Lancaster, , Martin R. Larsen

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

bioRxiv · Jun 4, 2026 · PreprintNeuroscience

Patient-Derived Air-Liquid Interface Forebrain Organoids Reveal Functional Synaptic Deficits in Schizophrenia

Lucrezia Criscuolo, Pia Jensen, Helle Bogetofte, Sissel Ida Schmidt, Fadumo Abdullahi Mohamed, Lene Andrup Jakobsen, Marie Sejberg Øhlenschlæger, Henriette Reventlow S Frederiksen, Fangyuan Li, Elif Bayram Orbe, Michael E. Benros, Jonathan Brewer, Barbara Lykke Lind, Phillip James Robinson, Kristine Freude, Martin R. Larsen

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

bioRxiv · Jun 3, 2026 · PreprintNeuroscience

Modeling Synaptic Maturation from Growth Cone to Synapse in Human Organoids

Marie Sejberg Øhlenschlæger, Lucrezia Criscuolo, Pia Jensen, Daniel J Lloyd-Davies Sanchez, Magdalena A. Sutcliffe, Santosh Bhosale, Helle Bogetofte, Muhammad Tahir, Lene Andrup Jakobsen, Maria Pihl, Jonathan Brewer, Veit Schwämmle, Frantz Rom Poulsen, Kristine Freude, Madeline A. Lancaster, , Martin R. Larsen

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

Journal of Neurochemistry · May 1, 2026Peer-reviewedNeuroscience

Multi-omic analysis of guided and unguided forebrain organoids reveal differences in cellular composition and metabolic profiles

Marie Sejberg Øhlenschlæger, Pia Jensen, Jesper Foged Havelund, Sissel Ida Schmidt, Fadumo Abdullahi Mohamed, Magdalena A. Sutcliffe, Sofie Blomberg Elmkvist, Lucrezia Criscuolo, Steven Wingett, Ilaria Chiaradia, Elif Bayram Orbe, Jeppe Allen Abildsten Nicolaisen, Lene Andrup Jakobsen, Jonathan Richard Brewer, Michael E. Benros, , Helle Bogetofte

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

Cell Reports Methods · Feb 1, 2026Peer-reviewedNeuroscience

Temporal proteomic and PTMomic atlas of cerebral organoid development

Sofie Blomberg Elmkvist, Helle Bogetofte, Pia Jensen, Lene Andrup Jakobsen, Jesper Foged Havelund, Matias Ryding, Jonathan Richard Brewer, Nils Joakim Færgeman, Madeline A. Lancaster, Martin R. Larsen

This study presents a temporal atlas of protein and PTM abundance in cerebral organoids, showing significant changes during development related to neuronal differentiation and energy metabolism.

bioRxiv · Sep 3, 2024 · PreprintNeuroscience