Martin R. Larsen

This study identifies N-glycosylation in Loxosceles venoms, revealing molecular heterogeneity and carbohydrate epitopes in toxins.

STEP-PTM enables integrated quantitative analysis of proteome, metabolome, and multiple PTM classes from single biological samples using a modular TMT-multiplexed workflow.

This paper introduces GPMAW glyco-search, a workflow for high-confidence identification of intact sialylated N-glycopeptides using TiO2 enrichment, dual LC-MS/MS, and interactive spectrum validation, achieving over 2800 identifications in human plasma.

This paper identifies HigX as a membrane-associated transcription factor in Caulobacter crescentus that is induced by the SOS response but negatively affects cell viability, revealing its role in cell envelope regulation and the trade-off between DNA repair and cell envelope stability.

This study uses forebrain organoids to show that schizophrenia involves sex-specific protein-state dysregulation, with changes in post-translational modifications and proteomic pathways rather than transcript levels.

This study uses patient-derived organoids to identify synaptic protein and phospho-regulatory deficits in schizophrenia.

This study uses brain organoids to show that miRNA dysregulation in schizophrenia leads to premature GABAergic maturation and neurodevelopmental defects.

This study develops a centrifugation protocol to isolate growth cones and immature synapses from human organoids, capturing synaptic development stages and enabling models for studying synaptic function and dysfunction.

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

This study shows that serum from critical COVID-19 patients alters proteomic profiles in olfactory neuroepithelial cells, linking systemic factors to neurological complications seen in Long COVID.

This study compares guided and unguided forebrain organoids using multi-omic analyses, revealing differences in cellular composition, metabolic profiles, and post-translational modifications.

This study quantifies cysteine redox dynamics in human T cells during early activation, revealing rapid remodeling of cysteine residues and their functional relevance in signaling pathways.

This study identifies factors affecting neural organoid generation by analyzing proteomic data and optimizes culture conditions to improve organoid quality.

This study shows that chronic morphine exposure alters the transcriptomic and proteomic content of brain-derived extracellular vesicles from the prefrontal cortex, which can reprogram recipient neurons.

This study isolates extracellular vesicles from postmortem brain tissue and uses multi-omics analysis to identify lipidomic and proteomic changes associated with substance use disorder.

This study identifies MrgD's role in modulating neurotransmission in the nigrostriatal pathway through proteomic analyses and behavioral assays, revealing impaired synaptic exocytosis and altered behavior in MrgD-deficient mice.

This study identifies gender-specific proteomic signatures in DEN-induced HCC by comparing differentially expressed proteins in male and female mice, revealing distinct pathways and prognostic markers.

The paper introduces ClimbMaster, an automated platform to assess exercise-induced adaptations in Drosophila, showing exercise improves endurance, fat loss, and insulin sensitivity, and rapamycin mitigates age-related decline.

This study presents a temporal atlas of protein and PTM abundance in cerebral organoids, showing significant changes during development related to neuronal differentiation and energy metabolism.

This study identifies angiotensin-(1-5) as a potent endogenous agonist of the AT2-receptor, showing its ability to increase nitric oxide release and lower blood pressure through AT2R-mediated mechanisms.

This study analyzes the proteomes of three Leishmania species under different growth phases and temperature stress to identify molecular changes during parasite-host interactions.

This study shows that modulating pseudoexon splicing in the PCCA gene with antisense oligonucleotides restores enzyme activity in propionic acidemia by rescuing PCCA and PCCB protein levels.

This study identifies experience-induced changes in the hippocampal PSD proteome and phosphoproteome in mice following inhibitory avoidance training or immediate shock.

This study uses a novel proteomics platform to identify PTM dysregulation in GBA-N370S PD neurons, revealing impaired neuritogenesis and a role for tau.

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

This study identifies site-specific changes in sialylation of N-linked glycoproteins in rat nerve terminals following brief depolarization.

This study shows that tau pathology develops spontaneously in APPswe/PS1ΔE9 mice, demonstrating that amyloidosis is necessary and sufficient to drive tauopathy in familial AD models.

This paper introduces a mass spectrometry-based strategy called TiCPG to simultaneously analyze proteome and three PTMs in cytokine-stimulated INS-1E cells, revealing extensive PTM regulation in beta-cell apoptosis pathways.