Epithelial-intrinsic nitric oxide synthase 2 sustains host-microbiota dynamics that promote colitis
Seika Hashimoto‐Hill, Bryce Hunt, Sekani Cole, Shikha Negi, Amanda Waddell, Zi F. Yang, Joseph A. Wayman, Nicholas Jay Ollberding, Emily R. Miraldi, Hee‐Woong Lim, Andrés Vázquez‐Torres, Thomas E. Morrison, Lee A. Denson, Theresa Alenghat
This study shows that epithelial nitric oxide synthase 2 (Nos2) influences host-microbiota interactions in IBD by regulating intestinal nitrates and nitrate-metabolizing bacteria, with implications for disease management.
bioRxiv · Sep 23, 2025 · PreprintImmunology