Lee A. Denson

This study shows that epithelial nitric oxide synthase 2 (Nos2) influences host-microbiota interactions in IBD by regulating intestinal nitrates and nitrate-metabolizing bacteria, with implications for disease management.

This study identifies IL-1β-inducing pathobionts in Crohn's disease that drive inflammation and may predict response to anti-TNF therapies.

The paper shows nutrient starvation activates ECM remodeling gene enhancers linked to IBD risk in fibroblasts, suggesting a mechanism for pathological fibroblast activation in IBD.

The paper tests eicosatetraynoic acid (ETYA) in a human intestinal organoid model to suppress pro-fibrotic pathways in macrophages associated with Crohn's Disease.

The paper links IBD polygenic risk to TNFi response using multiome-seq and genetic data from pediatric IBD patients.

The paper identifies methylation quantitative trait loci (mQTLs) in blood and ileum samples from Crohn's disease patients and finds they are largely consistent across disease states and tissues.

The paper uses measured and predicted gene expression to identify ulcerative colitis patients at elevated risk of colectomy, showing both methods independently replicate in multiple datasets.

The paper identifies 7 novel IBD-causing genes in Ashkenazi Jewish IBD patients using exome sequencing and analyzes their overlap with early-onset IBD and other diseases.