PQBP1 couples HIV-1 capsid recognition to cGAS recruitment through conformational remodeling
Dale Allen, Asit Kumar Manna, Christian Michel Beusch, Tian-hao Zhang, Barbie K. Ganser‐Pornillos, Juliana Piacentini, Seolhwa Oh, Savni Prabhu, Ayush Mehta, David Ezra Gordon, Owen Pornillos, Sunnie M. Yoh, Sumit K. Chanda
This study shows that HIV-1 capsid binding remodels PQBP1 conformation to enable cGAS recruitment, linking capsid recognition to innate immune activation.
bioRxiv · Jul 31, 2026 · PreprintMolecular Biology