Barbie K. Ganser‐Pornillos

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

This study shows lenacapavir remodels HIV-1 capsid structure by altering non-covalent interactions and material properties, leading to capsid rupture and impaired viral replication.

This study shows that HIV-1 capsid binding remodels PQBP1 conformation to enable cGAS recruitment, linking capsid recognition to innate immune activation.

This study identifies how dimeric HIV-1 RNA structures facilitate Gag protein assembly, revealing a structural mechanism for genome packaging.

This study determines the atomic structure of HIV-1 CACTD-SP1 assemblies with PF-46396 and IP6 using MAS NMR, revealing binding modes and IP6 dynamics.

This study shows that sequential binding of CypA and CPSF6 to HIV-1 capsid is necessary for nuclear entry and integration, and that lenacapavir targets this process.

The paper shows that Arg18 substitutions in HIV-1 capsid protein lead to non-fullerene capsid assembly with unique structural features.