Author

Ayush Mehta

Scripps Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Sumit K. ChandaiD· 2 shared Adolfo García‐SastreiD· 1 shared Asit Kumar MannaiD· 1 shared Barbie K. Ganser‐PornillosiD· 1 shared Christian Michel BeuschiD· 1 shared Dale AlleniD· 1 shared David Ezra GordoniD· 1 shared Dylan J. MendonsaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Sumit K. ChandaORCID

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2 papers

Recent·Most cited

Small molecule inhibition of the mitochondrial lipid transfer protein STARD7 attenuates influenza viral replication

Shipra Sharma, Oyahida Khatun, Jihaan Adonis, Shaochen You, Kevin Hartenbower, Vedita Anand Singh, Namir Shaabani, Saikat De, Emi R. Matsuo, Rachel Y. Sattler, Jonathan A. Covel, Kris M. White, Laura Martin‐Sancho, Malina A. Bakowski, Dylan J. Mendonsa, , Sumit K. Chanda

This paper identifies a small molecule, M4, that inhibits influenza A and B replication by targeting the host protein STARD7, preventing vRNP nuclear export and demonstrating synergistic antiviral effects with baloxavir in mice.

PLoS Pathogens · Sep 11, 2026Peer-reviewedMicrobiology

PQBP1 couples HIV-1 capsid recognition to cGAS recruitment through conformational remodeling

Dale Allen, Asit Kumar Manna, Christian Michel Beusch, Tian-hao Zhang, Barbie K. Ganser‐Pornillos, Juliana Piacentini, Seolhwa Oh, Savni Prabhu, Ayush Mehta, David Ezra Gordon, Owen Pornillos, Sunnie M. Yoh, Sumit K. Chanda

This study shows that HIV-1 capsid binding remodels PQBP1 conformation to enable cGAS recruitment, linking capsid recognition to innate immune activation.

bioRxiv · Jul 31, 2026 · PreprintMolecular Biology