Chromosomal rearrangements and instability caused by the LINE-1 retrotransposon
Carlos Mendez‐Dorantes, Xi Zeng, Jennifer A. Karlow, Phillip Schofield, Serafina Turner, Matthew Joseph Leventhal, Jupiter C. Kalinowski, Jinyu Wang, Sonia Zumalave, Jose M. C. Tubio, Eunjung Alice Lee, Kathleen H. Burns, Cheng-Zhong Zhang
This study uses whole-genome sequencing to show that LINE-1 retrotransposition directly causes chromosomal rearrangements and instability in cancer genomes.
bioRxiv · Dec 14, 2024 · PreprintGenomics