Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening
Ryan C. Locke, Liane M. Miller, Elisabeth A. Lemmon, Sereen S. Assi, Dakota L. Jones, Edward D. Bonnevie, Jason A. Burdick, Su Jin Heo, Robert L. Mauck
This study shows that transient nuclear softening with TSA treatment enhances cell migration and matrix formation in porcine meniscal cells, with full restoration of transcriptional phenotype and function within 7 days.
Acta Biomaterialia · Oct 9, 2025Peer-reviewedGenomics