Dakota L. Jones

Dysplastic Alveolar Basaloid Cells Provide a Protective Barrier via KRT17-Stratifin Complex during Chronic Fibrosis

The paper identifies KRT17-Stratifin complex as a protective barrier in dysplastic alveolar basaloid cells during chronic fibrosis, revealing mechanisms of alveolar metaplasia and its functional relevance.

Disease-associated mutations directionally modulate epigenetic age in iPSC-derived tissues

This study shows disease-associated mutations can directionally alter epigenetic age in iPSC-derived organoids, providing a model to study aging and disease interactions.

Cytoskeletal-nuclear control of alveolar fibroblast identity directs lung regeneration

This study shows that mechanical-nuclear signaling in alveolar fibroblasts influences lung regeneration by modulating transcriptional identity and epithelial repair after injury.

Divergent Pathways of Surfactant Protein C Maturation for Disease-Associated Isoforms

This study compares the maturation pathways of wild-type and disease-associated SP-C mutants, showing divergent trafficking and processing due to mutations.

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis

The paper establishes a human iPSC-derived co-culture model of pulmonary fibrosis that reveals bidirectional fibrogenic epithelial-mesenchymal crosstalk and identifies potential druggable pathways.

Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening

This study shows that transient nuclear softening with TSA treatment enhances cell migration and matrix formation in porcine meniscal cells, with full restoration of transcriptional phenotype and function within 7 days.

YAP regulates periosteal expansion in fracture repair

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

Alveolar epithelium propagates mechanical signals that control multi-cellular homeostasis in the lung

This study shows that alveolar epithelial type I cells propagate mechanical signals that affect lung homeostasis and disease states through intercellular communication.