Jason A. Burdick

Quantifying the role of hyaluronic acid on collagen fiber mechanics via femtosecond laser ablation

This study uses femtosecond laser ablation to measure collagen fiber recoil in tendons, showing that hyaluronic acid (HA) is critical for fiber sliding and mechanical properties.

Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening

This study shows that transient nuclear softening with TSA treatment enhances cell migration and matrix formation in porcine meniscal cells, with full restoration of transcriptional phenotype and function within 7 days.

Engineering kidney developmental trajectory using culture boundary conditions

This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.

Synovial fibroblasts support vascular function in an acute injury-on-a-chip model

This study develops an injury-on-a-chip model to investigate synovial fibroblasts' role in vascular function during acute inflammation, finding they support vascular health rather than drive disease.

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

Cytoplasmic CaMKIIδ-B prevents myocardial recovery in heart failure

The paper identifies CaMKIIδ-B subcellular localization as a determinant of myocardial recovery in heart failure, showing cytoplasmic retention impairs recovery.

Engineering nanoparticles that target fibroblast activation protein in cardiac fibrosis

This paper develops anti-FAP antibody-modified nanoparticles that target cardiac fibrosis in a rat model, reducing talabostat dose by 400,000-fold and reversing fibrosis and dysfunction.

Precision Repair of Zone-Specific Meniscal Injuries Using a Tunable Extracellular Matrix-Based Hydrogel System

This paper develops a tunable hydrogel system using decellularized meniscus extracellular matrix to repair zonal-specific meniscal injuries, showing improved cell differentiation and tissue integration.

Digital Light Processing 3D Printing enables High Throughput Fabrication of Human Engineered Heart Tissues for Disease Modeling

This paper introduces a DLP-based 3D printing method for rapid, high-efficiency fabrication of human engineered heart tissues to model cardiac disease.

Emergence of active contractile patterns alters monolayer force generation and transmission in response to focal adhesion distribution

This study shows that focal adhesion distribution affects force balance in epithelial monolayers, revealing non-uniform contractile patterns that alter force transmission.