Author

Ryan C. Locke

University of DelawareORCID 0000-0002-8466-3922Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Connor C. LeekiD· 1 shared Dakota L. JonesiD· 1 shared David M. OrnitziD· 1 shared Edward D. BonnevieiD· 1 shared Elahe GanjiiD· 1 shared Elisabeth A. LemmoniD· 1 shared Iman BhattacharyaiD· 1 shared Jaclyn M. Soulas· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperDevelopmental Biology

Connor C. LeekORCID

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2 papers

Recent·Most cited

GenomicsActa BiomaterialiaPeer-reviewedOct 9, 2025

Rapid Restoration of Cell Phenotype and Matrix Forming Capacity Following Transient Nuclear Softening

Ryan C. Locke, Liane M. Miller, Elisabeth A. Lemmon…·Robert L. Mauck

This study shows that transient nuclear softening with TSA treatment enhances cell migration and matrix formation in porcine meniscal cells, with full restoration of transcriptional phenotype and function within 7 days.

2 citations

experimental assay

𝕏 PostBluesky

Developmental BiologyDevelopmental DynamicsPeer-reviewedJun 6, 2021

Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments

Connor C. Leek, Jaclyn M. Soulas, Iman Bhattacharya…·Megan Leigh Killian

This study shows that deletion of Fgf9 in mice leads to enlarged deltoid tuberosities, suggesting a role for Fgf9 in muscle-bone interactions during development.

9 citations

mouseexperimental assay

𝕏 PostBluesky