OMA1-mediated cleavage of AIFM1 upon mitochondrial stress and suppression of cell growth through the control of OXPHOS activity
Mitsuhiro Nishigori, Serina Hirata, Hidetaka Kosako, Takeshi Ichinohe, Hendrik Nolte, Jan Riemer, Thomas Langer, Takumi Koshiba
The paper identifies AIFM1 as an OMA1 substrate that, when cleaved under mitochondrial stress, reduces OXPHOS activity and suppresses cell growth.
The EMBO Journal · Mar 24, 2026Peer-reviewedCell Biology