Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Yohsuke T. Fukai, Tomoya Kujirai, Masatoshi Wakamori, Setsuko Kanamura, Lisa Yamauchi, Somayeh Zeraati, Satoshi Morita, Chiharu Tanegashima, Mitsutaka Kadota, Mikako Shirouzu, Hitoshi Kurumizaka, Takashi Umehara, Kyogo Kawaguchi
This study reconstitutes gene-scale chromatin arrays with controlled histone modifications to show acetylation increases structural fluctuations and reduces nucleosome contact frequency.
Science Advances · Nov 19, 2025Peer-reviewedBiophysics