Author

Takashi Umehara

Ritsumeikan UniversityORCID 0000-0003-3464-2960Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Masatoshi WakamoriiD· 2 shared Aki MinodaiD· 1 shared Bogumił KaczkowskiiD· 1 shared Chiharu TanegashimaiD· 1 shared Chung-Chau HoniD· 1 shared Daichi NakamuraiD· 1 shared Gaku Furuie· 1 shared Hiroshi KimurâiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Masatoshi WakamoriORCID

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3 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedNov 19, 2025

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture

Yohsuke T. Fukai, Tomoya Kujirai, Masatoshi Wakamori…·Kyogo Kawaguchi

This study reconstitutes gene-scale chromatin arrays with controlled histone modifications to show acetylation increases structural fluctuations and reduces nucleosome contact frequency.

14 citationstop 5%

Hi-Clong-read sequencing

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BiophysicsEuropean Journal of Medicinal ChemistryPeer-reviewedMay 20, 2025

Temperature vaulting: A method for screening selective, slow- and tight-binding inhibitors targeting kinases in their non-native state

Sora Suzuki, Koji Umezawa, Gaku Furuie…·Isao Kii

This paper introduces a method called 'temperature vaulting' to screen inhibitors targeting kinases in their non-native state, demonstrating its effectiveness with the inhibitor FINDY (1) against DYRK1A.

1 citation

experimental assaydrug response / drug discovery

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Molecular BiologyEpigeneticsPeer-reviewedApr 3, 2018

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

Lusy Handoko, Bogumił Kaczkowski, Chung-Chau Hon…·Takashi Umehara

The paper investigates how JQ1 affects BRD2-dependent and independent transcription regulation without altering H4-hyperacetylated chromatin states in NSCLC cells.

37 citations

humanChIP-seq

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