Mikako Shirouzu

Therapeutic Potential of the Novel Monoclonal Antibody 7-4G against HBsAg in a Mouse Model of Chronic Hepatitis B Virus Infection

This study evaluates the antiviral activity of the monoclonal antibody 7-4G against HBsAg in a mouse model of chronic HBV infection, showing significant reduction in viral markers.

Secreted phospholipase PLA2G12A-driven lysophospholipid signaling via lipolytic modification of extracellular vesicles facilitates pathogenic Th17 differentiation

This study identifies PLA2G12A's role in Th17 differentiation through lysophospholipid signaling via extracellular vesicles, showing therapeutic potential for Th17-related diseases.

Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture

This study reconstitutes gene-scale chromatin arrays with controlled histone modifications to show acetylation increases structural fluctuations and reduces nucleosome contact frequency.

Carotenoid pigments enhance rhodopsin-mediated phototrophy by light-harvesting and photocycle-accelerating

The paper shows carotenoids enhance rhodopsin light utilization by accelerating photocycles and light-harvesting in marine bacteria.

Unidirectional ion transport mechanism of a light-driven chloride pump revealed using X-ray free electron lasers

This study reveals the unidirectional chloride transport mechanism in NM-R3 using TR-SFX, showing conformational changes and halide binding site insights.

Structural Basis for eIF2B Inhibition in Integrated Stress Response

The paper determines cryo-EM and crystal structures of eIF2B with phosphorylated and unphosphorylated eIF2 to reveal how eIF2 phosphorylation inhibits eIF2B activity.

Cryo-EM structure of the volume-regulated anion channel LRRC8

The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.