ITPKB is a conserved regulator of natural killer cell desensitization/education that constrains antitumor immunity
Yeara Jo, Alexandros Karampatzakis, Seung Won Lee, Alice Peng, Zaina Ghouri, Monsserratt Moya, Elizabeth Andrews, Harrison Sudholz, Chenyu Zhang, Berna Bou Tayeh, Alejandro N Medina, Jiucheng Ding, Robert A. Saxton, Ziyang Zhang, Yang Shi, , David H. Raulet
This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.
bioRxiv · Jul 17, 2026 · PreprintImmunology