David H. Raulet

This study identifies ITPKB as a regulator of NK cell desensitization, showing its inhibition enhances antitumor immunity in murine and human models.

This study shows that delivering cGAMP via bacteriophage MS2 nanoparticles enhances STING activation and antitumor immunity in mice.

Intra-tumoral Treg ablation enhances NK cell-mediated tumor control by restoring IL-2 production, effective against both MHC I+ and MHC I- cancers without systemic toxicity.

The paper identifies UFMylation as a suppressor of Type I IFN signaling during M. tuberculosis infection of human macrophages through a CRISPR-interference screen.

The paper investigates enhancer activity's role in random monoallelic expression (RME) of NK cell receptor genes, finding that enhancer properties drive RME and suggest it is a general phenomenon.