Seyed Ali Madani Tonekaboni

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

CREAM identifies COREs from cis-regulatory data, outperforming ROSE, and shows their enrichment near essential genes and TAD boundaries.

This study examines tissue-specific drug sensitivity in in vitro datasets and finds strong associations between tissue origin and drug response, but most preclinical findings do not align with clinical observations.

This paper introduces SIGN, a method for phenotype classification using gene expression patterns, showing it can classify cancer subtypes, identify cell types, and classify drugs based on mechanism of action.