Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer.
Geneviève Deblois, Seyed Ali Madani Tonekaboni, Yunchi Ingrid Kao, Felicia Tai, Xiaojing Liu, Ilias Ettayebi, Paul Guilhamon, Alexandra N. Fedor, Giacomo Grillo, Alexander J. Murison, Wail Ba-Alawi, David W. Cescon, C.H. Arrowsmith, Daniel DeCarvalho, Morag Park, , Mathieu Lupien
This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.
bioRxiv · Mar 28, 2018 · PreprintGenomics