Nehmé El-Hachem

Reference calibration, autozygosity and blood-derived variant interpretation in older adults

This study analyzes genetic variation in older Lebanese adults to distinguish reference sampling biases from true allele frequency differences and genotype expectations.

Inhibition of IL2Rβ-dependent STAT5 activity supports T-cell stemness and augments antitumor efficacy of CD8+ T cells by preventing T-cell exhaustion

Gene isoforms as expression-based biomarkers predictive of drug response in vitro

The paper identifies gene isoform-based biomarkers predictive of drug response in breast cancer using pharmacogenomic data from CCLE and GDSC.

PharmacoDB: an integrative database for mining in vitro anticancer drug screening studies

PharmacoDB integrates large pharmacogenomic studies to enable comparison and analysis of drug screening data by curating identifiers and standardizing drug response metrics.

Tissue specificity of in vitro drug sensitivity

This study examines tissue-specific drug sensitivity in in vitro datasets and finds strong associations between tissue origin and drug response, but most preclinical findings do not align with clinical observations.

Integrative pharmacogenomics to infer large-scale drug taxonomy

This paper introduces DNF, a computational framework that classifies new drugs by integrating structural, perturbation, and sensitivity data to infer drug relationships and taxonomies.

Similarity identification in gene expression patterns as a new approach in phenotype classification

This paper introduces SIGN, a method for phenotype classification using gene expression patterns, showing it can classify cancer subtypes, identify cell types, and classify drugs based on mechanism of action.