Author

Alexander J. Murison

University Health Network

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mathieu LupieniD· 2 shared Alexandra N. Fedor· 1 shared Alfred Thomas LookiD· 1 shared Amanda MitchelliD· 1 shared Angelica VaresiiD· 1 shared Benjamin Haibe‐KainsiD· 1 shared Boyang ZhangiD· 1 shared C.H. ArrowsmithiD· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioinformatics

Mathieu LupienORCID

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2 papers

Recent·Most cited

Distinct gene regulatory networks govern hematopoietic and leukemia stem cells

Boyang Zhang, Alexander J. Murison, Angelica Varesi, Naoya Takayama, Liqing Jin, Nathan Mbong, Erwin M. Schoof, Stephanie Zhi-Juan Xie, Amanda Mitchell, Julia Etchin, Alfred Thomas Look, Mathieu Lupien, Mark David Minden, Jean C. Y. Wang, Peter W. Zandstra, , Stanley W.K. Ng

This study identifies distinct gene regulatory networks in hematopoietic stem cells and leukemia stem cells using integrated gene expression and chromatin accessibility data from AML patients and human umbilical cord blood.

bioRxiv · Sep 28, 2024 · PreprintBioinformatics

Metabolic adaptations underlie epigenetic vulnerabilities in chemoresistant breast cancer.

Geneviève Deblois, Seyed Ali Madani Tonekaboni, Yunchi Ingrid Kao, Felicia Tai, Xiaojing Liu, Ilias Ettayebi, Paul Guilhamon, Alexandra N. Fedor, Giacomo Grillo, Alexander J. Murison, Wail Ba-Alawi, David W. Cescon, C.H. Arrowsmith, Daniel DeCarvalho, Morag Park, , Mathieu Lupien

This study identifies metabolic adaptations in taxane-resistant triple-negative breast cancer cells that lead to epigenetic vulnerabilities, specifically through altered methionine metabolism and H3K27me3 redistribution.

bioRxiv · Mar 28, 2018 · PreprintGenomics