Toxicity Management in CAR T cell therapy for B-ALL: Mathematical modelling as a new avenue for improvement.
Shalla Hanson, David Robert Grimes, Jake P. Taylor-King, Benedikt Bauer, Pravnam I. Warman, Ziv Frankenstein, Artem Kaznatcheev, Michael J. Bonassar, Vincent L. Cannataro, Zeinab Y. Motawe, Ernesto A. B. F. Lima, Sungjune Kim, Marco L. Davila, Arturo Araujo
This paper develops a mathematical model to explore toxicity in CAR T cell therapy for B-ALL, finding that initial tumour burden is a stronger predictor of toxicity than CAR T cell dose.
bioRxiv · Apr 22, 2016 · PreprintCancer Biology