Author

Vincent L. Cannataro

Primary ORCID profile (0000-0002-6364-7747 · 4 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Vincent L. CannataroiD4 papers · Emmanuel College - Massachusetts

Biology Disciplines

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Evolutionary Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Colette M. St. Mary· 2 shared Scott A. McKinley· 2 shared Artem Kaznatcheev· 1 shared Arturo Araujo· 1 shared Benedikt Bauer· 1 shared David Robert Grimes· 1 shared Ernesto A. B. F. Lima· 1 shared Jake P. Taylor-King· 1 shared

Activity by Year

2015-2016 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersEvolutionary Biology

Colette M. St. Mary

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3 papers

Recent·Most cited

The Evolutionary Trade-off between Stem Cell Niche Size, Aging, and Tumorigenesis

Vincent L. Cannataro, Scott A. McKinley, Colette M. St. Mary

This paper develops a mathematical model of intestinal stem cell niches to show how mutation accumulation affects aging and tumorigenesis through genetic drift and niche size trade-offs.

bioRxiv · Jun 15, 2016Evolutionary Biology

Toxicity Management in CAR T cell therapy for B-ALL: Mathematical modelling as a new avenue for improvement.

Shalla Hanson, David Robert Grimes, Jake P. Taylor-King, Benedikt Bauer, Pravnam I. Warman, Ziv Frankenstein, Artem Kaznatcheev, Michael J. Bonassar, Vincent L. Cannataro, Zeinab Y. Motawe, Ernesto A. B. F. Lima, Sungjune Kim, Marco L. Davila, Arturo Araujo

This paper develops a mathematical model to explore toxicity in CAR T cell therapy for B-ALL, finding that initial tumour burden is a stronger predictor of toxicity than CAR T cell dose.

bioRxiv · Apr 22, 2016 · PreprintCancer Biology

The Implications of Small Stem Cell Niche Sizes and the Distribution of Fitness Effects of New Mutations in Aging and Tumorigenesis

Vincent L. Cannataro, Scott A. McKinley, Colette M. St. Mary

The paper uses simulations to analyze how stem cell niche size and mutation effects influence tumorigenesis and aging, finding that whole-organism DFEs can explain tumor incidence despite small stem cell populations.

bioRxiv · Nov 24, 2015Evolutionary Biology