Chromatin modifiers KMT2D, BAF, and p300 are required for de novo binding of transcription factors on enhancers
Hieu T. Van, Young-Kwon Park, Chengyu Liu, Shamima Islam, Stefania Dell’Orso, Weiqun Peng, Vittorio Sartorelli, Ji‐Eun Lee, Kai Ge
The paper shows that chromatin modifiers KMT2D, BAF, and p300 are required for de novo TF binding on enhancers, revealing cooperative interactions rather than a strict hierarchy.
bioRxiv · Jan 29, 2026 · PreprintMolecular Biology