Kai Ge

KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis

This study shows that KMT2C and KMT2D regulate skeletal development through epigenetic control of chondrogenesis, with redundancy in their function during bone formation.

Histone Chaperone HIRA regulates adiponectin expression and obesity-associated adipose expansion by facilitating Pol II pause release

This study identifies HIRA as an epigenomic regulator of adipose tissue function, showing it promotes adiponectin and lipid metabolism gene expression by facilitating RNA polymerase II pause release.

MLL3 adaptor function, not methyltransferase catalytic activity, is essential for breast tumor suppression

This study shows that MLL3's tumor suppressor role in breast cancer depends on its adaptor function, not its catalytic activity.

ISWI remodeler facilitates cBAF genomic binding to drive cell fate transition

This study shows ISWI remodelers are essential for muscle and adipose development and link LDTF binding to cBAF recruitment during cell fate transition.

MLL3 and MLL4 sustain hematopoietic stem cell multipotency by opposing a B-cell default state

This study shows that MLL3 and MLL4 maintain hematopoietic stem cell multipotency by opposing a B-cell default state through distinct enhancer regulation mechanisms.

Chromatin modifiers KMT2D, BAF, and p300 are required for de novo binding of transcription factors on enhancers

The paper shows that chromatin modifiers KMT2D, BAF, and p300 are required for de novo TF binding on enhancers, revealing cooperative interactions rather than a strict hierarchy.

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner

This study shows that MLL3/MLL4 methyltransferase activities are essential for early embryonic development and stem cell differentiation, but their role is lineage-selective and not dependent on enhancer activation.

Interplay of BAF and MLL4 promotes cell type-specific enhancer activation

This study shows BAF and MLL4 work together to activate cell type-specific enhancers during adipogenesis, with BAF being essential for differentiation while PBAF is not.

MED1 is a lipogenesis coactivator required for postnatal adipose expansion

This study shows MED1 is essential for postnatal adipose expansion and de novo lipogenesis gene induction in mice, but not for adipose development or early adipogenesis.

H3.3K4M destabilizes enhancer epigenomic writers MLL3/4 and impairs adipose tissue development

This study shows that H3.3K4M destabilizes MLL3/4 proteins, preventing enhancer activation and impairing adipose tissue development.

Histone H3 Lysine 4 methyltransferases MLL3 and MLL4 Modulate Long-range Chromatin Interactions at Enhancers

This study shows that MLL3/4 proteins regulate chromatin interactions at enhancers by depositing H3K4me1, which recruits Cohesin to facilitate chromatin looping.