Vittorio Sartorelli

Chromatin modifiers KMT2D, BAF, and p300 are required for de novo binding of transcription factors on enhancers

The paper shows that chromatin modifiers KMT2D, BAF, and p300 are required for de novo TF binding on enhancers, revealing cooperative interactions rather than a strict hierarchy.

The DND1-NANOS3 complex shapes the primordial germ cell transcriptome via a heptanucleotide sequence in mRNA 3'UTRs

The paper identifies an RNA sequence motif recognized by the DND1-NANOS3 complex in germ cells and shows its role in regulating mRNA expression.

Transcriptomics, Regulatory Syntax, and Enhancer Identification in Heterogenous Populations of Mesoderm-Induced ESCs at Single-Cell Resolution

This study uses bulk and single-cell assays to analyze gene expression, histone modifications, and chromatin features in ESCs transitioning to mesoderm lineages, identifying cis-regulatory elements and transcription factors involved in lineage specification.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

The paper identifies RUNX1-independent mechanisms for hematopoietic stem cell generation and shows that GATA2 and RUNX1 functionally complement each other in hematopoiesis.

Dynamic Sex Chromosome Expression in Drosophila Male Germ Cells

The paper shows that X and 4th chromosomes are inactivated while Y chromosomes are active in Drosophila primary spermatocytes using single-cell RNA-Seq.

Integration of a Computational Pipeline for Dynamic Inference of Gene Regulatory Networks in Single Cells

The paper introduces an integrated computational pipeline for inferring gene regulatory networks in single cells without prior knowledge, improving accuracy by combining data dimensions and visualizing gene interactions across developmental stages.