Author

Shamsa Roshan

Icahn School of Medicine at Mount Sinai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Bruno CogliatiiD· 2 shared Federico Di TullioiD· 2 shared Lida YangiD· 2 shared Sai MaiD· 2 shared Sue Bin Yang· 2 shared Tianliang SuniD· 2 shared Abigail GlezeriD· 1 shared Amaia LujambioiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersCancer Biology

Bruno CogliatiORCID

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2 papers

Recent·Most cited

Liver Zonation Disruption Fuels Hepatocellular Carcinoma in Chronic Liver Disease

Sue Bin Yang, Federico Di Tullio, Lida Yang, Bruno Cogliati, Désirée Schnidrig, Andrej Benjak, Shamsa Roshan, Joana I. Almeida, Lilian Yanqing Li, Sai Ma, Jan S. Tchorz, Charlotte K.Y. Ng, Tianliang Sun

This study identifies zonation disruption, specifically aberrant β-catenin expansion, as a novel driver of hepatocellular carcinoma in chronic liver disease, revealing a distinct human HCC subtype with therapeutic implications.

bioRxiv · Dec 10, 2025 · PreprintCancer Biology

Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease

Federico Di Tullio, Sue Bin Yang, Lida Yang, Bruno Cogliati, Shamsa Roshan, Kaiyuan Guo, Abigail Glezer, Joseph Conrad, Siddarth Vinod Kumar, Joana Almeida, Haoyuan Li, Shahina Saeed, Marina Bárcena‐Varela, Emily R. Bramel, Anthony Lozano, , Tianliang Sun

This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.

bioRxiv · Jun 19, 2025 · PreprintCell Biology