Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease
Federico Di Tullio, Sue Bin Yang, Lida Yang, Bruno Cogliati, Shamsa Roshan, Kaiyuan Guo, Abigail Glezer, Joseph Conrad, Siddarth Vinod Kumar, Joana Almeida, Haoyuan Li, Shahina Saeed, Marina Bárcena‐Varela, Emily R. Bramel, Anthony Lozano, , Tianliang Sun
This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.
bioRxiv · Jun 19, 2025 · PreprintCell Biology