Anthony Lozano

B cells sustain tumor-specific CD4 T cells to promote response to PD-1 targeted therapy

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

Bacteroidetes promote hepatocellular carcinoma progression and resistance to immunotherapy

This study identifies Bacteroidetes enrichment as a biomarker of immunotherapy resistance in hepatocellular carcinoma and shows its pro-tumorigenic effects in mouse models.

Targeting ZNRF3 and RNF43 to Restore Regeneration and Reverse Metabolic Dysfunction-Associated Steatotic Liver Disease

This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.

NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinoma

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.