Amaia Lujambio

This study shows that B cells support tumor-specific CD4 T cells to enhance PD-1 blockade efficacy, but antibody secretion is not necessary for long-term survival.

This study identifies the role of mature dendritic cells type 1 in forming, maintaining, and functioning tertiary lymphoid structures in cancer.

This study identifies Bacteroidetes enrichment as a biomarker of immunotherapy resistance in hepatocellular carcinoma and shows its pro-tumorigenic effects in mouse models.

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

This paper identifies SLU7 as a pan-cancer target, showing its knockdown induces genomic instability and enhances immunogenicity, with effective tumor suppression in murine models.

This study shows that deleting ZNRF3 and RNF43 in hepatocytes after MASH onset restores liver regeneration and reverses steatosis, inflammation, and fibrosis without causing tumorigenesis or hepatotoxicity.

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.

This study shows ICOS limits the function of exhausted PD-1+ CD8 T cells by promoting their differentiation into less functional effector-like cells, and inhibiting ICOS improves anti-tumor responses.