A bone marrow stromal secretome screen identifies semaphorin 3A as a regulator of hematopoiesis
Daniel K. Borger, Shane Mitchell, Fumio Nakahara, Daniele Colombo, Lidiane S. Torres, S. Garforth, Simone Sidoli, Jeroen Krijgsveld, Lev Silberstein, Paul S. Frenette, Kira Gritsman
The paper identifies semaphorin 3A as a secreted factor from revitalized MSCs that regulates HSPC proliferation in steady state and stress conditions.
bioRxiv · Aug 7, 2025 · PreprintCell Biology