Kira Gritsman

This study identifies a resistance mechanism in AML leukemic stem cells to PI3K inhibition and shows that combining PI3K and EZH1/2 inhibitors overcomes resistance.

This paper shows that targeting STAT3 with a degrader can overcome Venetoclax resistance in AML by reducing MCL1 and improving mitochondrial function.

The paper identifies semaphorin 3A as a secreted factor from revitalized MSCs that regulates HSPC proliferation in steady state and stress conditions.

This study identifies TTLL4 as a therapeutic target in NPM1-mutated AML by showing its role in stabilizing NPM1c and promoting differentiation block, with a small molecule inhibitor demonstrating efficacy.

This study shows that partial deletion of RpS12 in mice causes defects in erythropoiesis and hematopoietic stem cell maintenance, leading to embryonic lethality and pancytopenia.