Identifying Novel Therapeutic Targets for Overcoming TNBC Chemo Resistance Through Comprehensive CRISPR-Cas9 Genome Screening
Shuai Shao, Shangjia Li, Yang Huo, Shan Tang, Birkan Gökbağ, Kunjie Fan, Yirui Huang, Lingling Wang, Gregory Nagy, Jeffrey D. Parvin, Daniel G. Stover, Lijun Cheng, Lang Li
This study uses CRISPR-Cas9 and RNAseq to identify novel synthetic lethal targets in TNBC cells resistant to cisplatin/doxorubicin, highlighting potential drug targets for combination therapies.
Cancers · Dec 3, 2025Peer-reviewedCancer Biology