Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability protected by heavy m6A modification
Pei-Yi Su, Yun-Hua Lin, Shania Foustine, C Y Chang, Ankit Gupta, Brian N. Papas, Wiep van der Toorn, Max von Kleist, Redmond P. Smyth, Marcos Morgan, Pei‐Jer Chen, Kevin Tsai
This study uses Nanopore DRS to show m6A modification on HBV RNA enhances stability by protecting long poly(A) tails, supporting m6A as an antiviral target.
bioRxiv · Apr 8, 2025 · PreprintMicrobiology