Max von Kleist

The paper introduces an improved protocol and software for sequence-specific direct RNA sequencing of non-polyadenylated RNAs, validated on human rRNA and other RNA species.

The paper investigates the role of hypothalamic NPY/AgRP neurons in regulating age-related presynaptic remodeling through autophagy and non-cell autonomous mechanisms.

The paper shows that homozygosity in Drosophila mercatorum reduces phenotypic robustness, leading to increased developmental instability and reduced survival under stress.

SIMPLICITY models SARS-CoV-2 intra- and between-host evolution, showing that immune waning and infection history drive realistic evolutionary dynamics.

WarpDemuX-tRNA improves barcode multiplexing for nanopore tRNA sequencing with higher precision and efficiency.

The paper introduces MoDorado, an algorithm that detects tRNA modifications beyond those trained in existing models, identifying seven new modifications in S. pombe.

WarpDemuX improves multiplexing accuracy and speed for nanopore dRNA-seq, enabling efficient phenotyping of SARS-CoV-2 variants and real-time RNA enrichment.

This study uses Nanopore DRS to show m6A modification on HBV RNA enhances stability by protecting long poly(A) tails, supporting m6A as an antiviral target.

This study evaluates sequencing accuracy and systematic errors in direct RNA sequencing across species and synthetic RNA, identifying error patterns and their implications for downstream applications.

This paper models the efficacy and toxicity of islatravir as oral and subdermal PrEP, finding implants offer safer efficacy while oral dosing has toxicity risks.

This paper introduces SSATAN-X, a stochastic simulation algorithm for pathogen spreading on adaptive networks, achieving up to 100x speed-up over existing methods.

The paper introduces three numerical methods to directly compute prophylactic efficacy from a viral dynamics model without stochastic simulation, improving computational performance for PrEP analysis.

This paper shows that inferring gene regulatory networks from scRNA-seq data requires considering higher-order statistical moments and highlights challenges in preprocessing and feature extraction.

The paper shows that temperature-dependent changes in synaptic partner availability lead to variable connectivity and behavior in Drosophila without affecting canonical synapse ratios.

The paper shows that autophagy regulates axonal filopodia kinetics, which restricts incorrect synaptic partner choice during Drosophila brain development.

The paper develops a 4D analysis method and computational model to show that filopodia compete for synaptic seeding factors, leading to serial synapse formation in Drosophila R7 photoreceptor axons.