Wiep van der Toorn

The paper introduces an improved protocol and software for sequence-specific direct RNA sequencing of non-polyadenylated RNAs, validated on human rRNA and other RNA species.

WarpDemuX-tRNA improves barcode multiplexing for nanopore tRNA sequencing with higher precision and efficiency.

The paper introduces MoDorado, an algorithm that detects tRNA modifications beyond those trained in existing models, identifying seven new modifications in S. pombe.

WarpDemuX improves multiplexing accuracy and speed for nanopore dRNA-seq, enabling efficient phenotyping of SARS-CoV-2 variants and real-time RNA enrichment.

This study uses Nanopore DRS to show m6A modification on HBV RNA enhances stability by protecting long poly(A) tails, supporting m6A as an antiviral target.

This study evaluates sequencing accuracy and systematic errors in direct RNA sequencing across species and synthetic RNA, identifying error patterns and their implications for downstream applications.